EPNOE Workshop Polysaccharides in Drug Delivery - On the Road to Innovation!
October 27-28, 2022
Rome, Italy

Invited lecture:
Thiolated Polysaccharides: From the Bench to Market
Prof. Dr. A. Bernkop-Schnürch
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ThioMatrix’s drug delivery technologies are mainly based on thiolated polymeric excipients or designated thiomers. Due to the immobilization of thiol groups on already well-established polymeric excipients such as polyacrylates or chitosans the following features are strongly improved:

• mucoadhesive properties more....

• permeation enhancing effect more....

• capability to provide a controlled drug release more....

• enzyme inhibtory properties more....
  
  
• in-situ gelling features more....
  
  
• efflux pump inhibition more....

Self-Emulsifying Drug Delivery Systems

Thiomatrix is also specialized on the design and development of self-nanoemulsifying and self-microemulsifying drug delivery systems (SNEDDS; SMEDDS) collectively summarized as self-emulsifying drug delivery systems (SEDDS). In particular we develop SEDDS providing:

• a protective effect towards a presystemic metabolism more....
  
  
• high mucus permeating properties more....
  
  
• high mucoadhesive properties more....
  
  
• high spreading properties on the mucosa more....
  
  
• permeation enhancing properties more....
  
  

Based on various in-house generated technologies we can incorporate also hydrophilic macromolecular drugs such as therapeutic peptides and DNA/RNA-based drugs in SEDDS.

A. Bernkop-Schnürch, CSO ThioMatrix, was honored with the Gattefossé North America Award 2017
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