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Events

5th International Conference and Exhibition on Pharmaceutical Science and Technology
June 21-23, 2022
Bangkok, Thailand

Invited lecture:
Lipid-based Nanocarriers for Oral Delivery of Therapeutic Peptides: Hype or Hope?
Prof. Dr. A. Bernkop-Schnürch
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13th Global Drug Delivery & Formulation Summit
June 27-29, 2022
Berlin, Germany

Invited lecture:
Novel Nanotechnologies for Mucosal Delivery of Small Molecules and Biologics: Old Problems but New Solutions
Prof. Dr. A. Bernkop-Schnürch
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DisintegrationDisintegration behaviour of tablets based on polycarbophil (PCP) and sodium carboxymethyl-cellulose (CMC) (grey bars) and of the corresponding thiolated polymers (blue bars) [Bernkop-Schnürch, A., Scholler, S., and Biebel, R.G. (2000). Development of controlled drug release systems based on polymer-cysteine conjugates. J. Cont. Rel, 66, 39].

 

Release

Release profile of fluoresein from tablets based on poly(acrylic acid) (grey graph) and from tablets based on thiolated poly(acrylic acid) (blue graph) [Hornof, M.D., Weyenberg, W., Ludwig, A., and Bernkop– Schnürch, A. (2003). A mucoadhesive ocular insert: Development and in vivo evaluation in humans. J. Cont. Rel. 89, 419].

 

 

Controlled Drug Release


Due to a sustained drug release, a prolonged therapeutic level of drugs exhibiting a short elimination half-live can be maintained. Consequently the frequency of dosing can be reduced contributing to an improved compliance. The release of drugs out of polymeric carrier systems can be controlled by a simple diffusion process. So far the efficacy of such delivery systems, however, was limited by a too rapid disintegration and/or erosion of the polymeric network [Bernkop-Schnürch, A., Scholler, S., and Biebel, R.G. (2000). Development of controlled drug release systems based on polymer-cysteine conjugates. J. Control. Release, 66, 39; Clausen, A.E., and Bernkop-Schnürch, A. (2001) Development and in vitro evaluation of a peptide drug delivery system based on thiolated polycarbophil. Pharm. Ind., 63, 312]. By using thiolated polymers this essential shortcoming can be overcome. Because of the formation of inter- and intrachain disulfide bonds during the swelling process, the stability of the polymeric drug carrier matrix is strongly improved. Hence, a controlled drug release for numerous hours is guaranteed. This controlled drug release has also been demonstrated by studies in human volunteers.

 

 

 

 

 

 

 

 

 

 

  News

A. Bernkop-Schnürch, CSO ThioMatrix, was honored with the Gattefossé North America Award 2017
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