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14th Hellenic Polymer Society International Conference
22-25 November, 2023, Thessaloniki, Greece
Invited lecture:
Thiolated Polymers – Thiomers: Utilizing the most prominent bridging structure designed by nature
Prof. Dr. A. Bernkop-Schnürch
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2nd Edition International Conference on Nanotechnology & Materials Science
Conference
September 23-25, 2024
Paris, France
Invited lecture:
Thiolated Nanocarriers for Drug Delivery: Mimicking the Workhorses of Our Body
Prof. Dr. A. Bernkop-Schnürch
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 Degradation of the peptide
drug leu-enkephalin by aminopeptidase N(grey graph). Due to the addition of 0.5% thiomer drug stability is significantly improved (blue graph) [Bernkop-Schnürch, A., Zarti, H. and Walker, G.F. (2001) Thiolation of polycarbophil enhances its inhibition of soluble and intestinal brush border membrane bound aminopeptidase N. J. Pharm. Sci., 90, 1907].
 Hydrolysis of the substrate
hippuryl-L-phenylalanine (HPA) to L-phenylalanine (PA) and hippuric acid by
carboxypeptidase A (grey graph). Due to the addition of 012.5% thiomer drug stability is significantly improved (blue graph). [Bernkop-Schnürch, A. and Thaler, S.
(2000). Polycarbophil-cysteine conjugates as platforms for oral (poly)peptide
delivery systems. J. Pharm. Sci., 89, 901]
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Enzyme Inhibition
Many non-invasively administered drugs such as therapeutic peptides or nucleic
acids are degraded on the mucosa by membrane bound enzymes strongly reducing
their bioavailability. In case of oral administration this ‘enzymatic
barrier’ is even more pronounced as an additional degradation caused by
luminally secreted enzymes takes place. Because of their capability to bind
Zn2+ ions via thiol groups, thiomers are potent inhibitors of most membrane
bound and secreted zinc-dependent enzymes.Due to this enzyme inhbitory effect, thiomers can sginificantly improve the bioavailability of non-invasively administered drugs.
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News
A. Bernkop-Schnürch, CSO ThioMatrix, was honored with the Science Award of Tyrol 2023
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ThioMatrix Hotline:
+43 512 890046
Mo-Th 9.00-17.00
and Fr 9.00-14.00
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Download references about thiomers
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