|
| Events
14th Hellenic Polymer Society International Conference
22-25 November, 2023, Thessaloniki, Greece
Invited lecture:
Thiolated Polymers – Thiomers: Utilizing the most prominent bridging structure designed by nature
Prof. Dr. A. Bernkop-Schnürch
more...
2nd Edition International Conference on Nanotechnology & Materials Science
Conference
September 23-25, 2024
Paris, France
Invited lecture:
Thiolated Nanocarriers for Drug Delivery: Mimicking the Workhorses of Our Body
Prof. Dr. A. Bernkop-Schnürch
more...
|
|
Correlation between the
decrease in thiol groups (graph) because of the formation of disulfide bonds
and the increase in viscosity (bars) of thiolated chitosan [Hornof, M.D., Kast, C.E., and Bernkop-Schnürch, A. (2003). In vitro evaluation of the viscoelastic properties of chitosan - thioglycolic acid conjugates. Eur J. Pharm. Biopharm., 55, 185].
|
|
In Situ Gellation
Various polymers are capable
of prolonging the residence time of drug delivery systems by their in-situ
gelling properties. For instance, deacetylated gellan gum is used in eye
drops (Timoptic XE; CibaVision) in order to
prolong the precorneal residence time of the incorporated drug. Such in-situ
gelling properties are also beneficial for numerous other drug delivery
systems improving the bioavailability and prolonging the drug action [Park J.S., Oh Y.K., Yoon H., Kim J.M., and Kim C.K. (2002). In situ gelling and mucoadhesive polymer vehicles for controlled intranasal delivery of plasmid DNA. J. Biomed Mater. Res.,59, 144; Bromberg, L.E. (2001) Enhanced nasal retention of hydrophobically modified polyelectrolytes. J. Pharm. Pharmacol. 53, 109; Paulsson M., Hagerstrom H., and Edsman K. (1999). Rheological studies of the gelation of deacetylated gellan gum (Gelrite) in physiological conditions. Eur. J. Pharm. Sci., 9, 99]. In comparison
to so far used in-situ gelling polymers, thiolated polymers are capable of
providing a comparatively more pronounced increase in viscosity after
application, as an extensive crosslinking process by the formation of
disulfide bonds between the polymer chains takes place. For instance, in
case of thiolated chitosan a more than 1000-fold increase in viscosity by
the formation of disulfide bonds within the polymeric network based on a
simple oxidation process was shown [Bernkop-Schnürch, A., Hornof, M. and Zoidl, T. (2003). Thiolated polymers – thiomers: modification of chitosan with 2-iminothiolane, Int. J. Pharm., 260, 229]. Being applied in liquid form, they become highly viscous gels for instance
in the nasal cavity or in the vagina, which avoids an unintended rapid
elimination of the semisolid delivery system.
|
|
News
A. Bernkop-Schnürch, CSO ThioMatrix, was honored with the Science Award of Tyrol 2023
more....
|
|
ThioMatrix Hotline:
+43 512 890046
Mo-Th 9.00-17.00
and Fr 9.00-14.00
Print this page
|
Download references about thiomers
|
|
