14th Hellenic Polymer Society International Conference
22-25 November, 2023, Thessaloniki, Greece

Invited lecture: Thiolated Polymers – Thiomers: Utilizing the most prominent bridging structure designed by nature

Prof. Dr. A. Bernkop-Schnürch
more...

2nd Edition International Conference on Nanotechnology & Materials Science
Conference
September 23-25, 2024
Paris, France

Invited lecture:
Thiolated Nanocarriers for Drug Delivery: Mimicking the Workhorses of Our Body

Prof. Dr. A. Bernkop-Schnürch
more...

Solubility Enhancement Studies

ThioMatrix has great experience in formulation of poorly soluble APIs. In order to overcome solubility problems, ThioMatrix has developed a rational screening platform aimed at finding cost-effective and quick solutions to support such studies. After a solubility screening and cristallinity assessment the identified poor solubility of APIs can bee enhanced by:

• solidlid-state modifications such as salt formation, particle size reduction or solid-state stabilization of the amorphous state
  
  
• addition of co-solvents
  
  
• development of lipid based systems such as microemulsions
  
  
• formation of complexes such as with cyclodextrins
  
  
• addition of additives such as surfactants or polymer
  
  
• Sufficient solubility is a prerequisite for essential in vitro analyses such as permeation studies and subsequently the development of highly efficient drug delivery systems.

Sufficient solubility is a prerequisite for essential in vitro analyses such as permeation studies and subsequently the development of highly efficient drug delivery systems.

A. Bernkop-Schnürch, CSO ThioMatrix, was honored with the Science Award of Tyrol 2023
more....