14th Hellenic Polymer Society International Conference
22-25 November, 2023, Thessaloniki, Greece

Invited lecture: Thiolated Polymers – Thiomers: Utilizing the most prominent bridging structure designed by nature

Prof. Dr. A. Bernkop-Schnürch
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2nd Edition International Conference on Nanotechnology & Materials Science
Conference
September 23-25, 2024
Paris, France

Invited lecture:
Thiolated Nanocarriers for Drug Delivery: Mimicking the Workhorses of Our Body

Prof. Dr. A. Bernkop-Schnürch
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Permeation Studies

Based on results gained from permeation studies in Ussing-type chambers with intestinal, nasal, buccal or vaginal mucosal membranes from various species or permeation studies on various monolayers such as Caco-2 substantial information about drug permeability is provided. This information includes:

• the apparent permeability coefficient (Papp) of the drug
  
  
• the route of uptake (transcellular vs. paracellular; active and/or passive etc.)
  
  
• degree of presystemic metabolism of the drug
  
  
• membrane toxicity
  
  
• impact of well-established permeation enhancers on drug uptake

This information will be the basis for:

• first bioavailability estimations
  
  
• slight chemical modifications of the molecule in order to improve its performance from the biopharmaceutical point of view (prodrug development; the use of another salt etc.)
  
  
• any decision concerning the route of application (e.g. s.c. injection or oral dosage form)
  
  
• the design and development of highly efficient delivery systems

In vitro/ex vivo permeation studies allow the reduction of many cost-intensive and time-consuming in vivo studies. The screening of numerous drug candidates can be completed by ThioMatrix within a few weeks. The service package will be tailored exactly to the customer's specific requirements and includes the full interpretation of generated data.

A. Bernkop-Schnürch, CSO ThioMatrix, was honored with the Science Award of Tyrol 2023
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