14th Hellenic Polymer Society International Conference
22-25 November, 2023, Thessaloniki, Greece

Invited lecture: Thiolated Polymers – Thiomers: Utilizing the most prominent bridging structure designed by nature

Prof. Dr. A. Bernkop-Schnürch
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2nd Edition International Conference on Nanotechnology & Materials Science
Conference
September 23-25, 2024
Paris, France

Invited lecture:
Thiolated Nanocarriers for Drug Delivery: Mimicking the Workhorses of Our Body

Prof. Dr. A. Bernkop-Schnürch
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Nasal Drug Delivery Systems

Drug delivery through the nose offers the advantage of a comparatively rapid onset of action that is essential for the treatment of e.g. pain relief, erectile dysfunction or nausea. In comparison to oral drug delivery systems a higher bioavailability of peptide drugs in particular by utilizing the thiomer-technology can be achieved. ThioMatrix is well versed in the design and development of liquid, semisolid and solid nasal drug delivery systems. The development includes:

• orientating permeation studies on nasal membranes
  
  
• evaluations of the stability of the drug on the nasal mucosa towards membrane bound enzymes
  
  
• orientating toxicity studies (cytotoxicity studies; ciliary beat frequency studies; histological examinations; etc.)
  
  
• optimisation of the delivery system
  
  
• storage stability studies
  
  
• in vivo pharmacokinetic studies in various animal species
  
  
• orientating studies in humans

Our recent publications in this field:

Hebar A, Koller C, Seifert JM, Chabicovsky M, Bodenteich A, Bernkop-Schnürch A, Grassauer A, Prieschl-Grassauer E. Non-clinical safety evaluation of intranasal iota-carrageenan. PLoS One. 2015 Apr 13;10(4)
Millotti G, Vetter A, Leithner K, Sarti F, Shahnaz Bano G, Augustijns P, Bernkop-Schnürch A. Development of thiolated poly(acrylic acid) microparticles for the nasal administration of exenatide. Drug Dev Ind Pharm. 2014 Dec;40(12):1677-82.
Shahnaz G, Vetter A, Barthelmes J, Rahmat D, Laffleur F, Iqbal J, Perera G, Schlocker W, Dünnhaput S, Augustijns P, Bernkop-Schnürch A. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. Int J Pharm. 2012 May 30;428(1-2):164-70.
Vetter A, Augustijns P, Bernkop-Schnürch A. Solubilizing agents in nasal formulations and their effect on ciliary beat frequency.  Toxicol In Vitro. 2012 Feb;26(1):150-6.
Palmberger TF, Augustijns P, Vetter A, Bernkop-Schnürch A. Safety assessment of thiolated polymers: effect on ciliary beat frequency in human nasal epithelial cells. Drug Dev Ind Pharm. 2011 Dec;37(12):1455-62.
Vetter A, Bernkop-Schnürch A. Nasal delivery of antisense oligonucleotides: in vitro evaluation of a thiomer/glutathione microparticulate delivery system.  J Drug Target. 2010 May;18(4):303-12.
Vetter A, Martien R, Bernkop-Schnürch A. Thiolated polycarbophil as an adjuvant for permeation enhancement in nasal delivery of antisense oligonucleotides. J Pharm Sci. 2010 Mar;99(3):1427-39.

Download a brochure (Nasal Drug Delivery)

Download a brochure (Non-invasive Peptidel Drug Delivery)

A. Bernkop-Schnürch, CSO ThioMatrix, was honored with the Science Award of Tyrol 2023
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