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2025

Illustration of lipidation techniques, including covalent lipidation, hydrophobic ion pairing, and reverse micelles for enhanced drug delivery.

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

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Diagram of CBD delivery systems, showing mucus permeation, lipid digestion graphs, and plasma CBD levels in a mouse model after oral administration.

Oral formulations for cannabidiol: Improved absolute oral bioavailability of biodegradable cannabidiol self-emulsifying drug delivery systems

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Diagram showing intraoral drug delivery with barriers, strategies, and formulation approaches like patches, sprays, and tablets above a tissue cross-section.

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

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Illustration depicting SEDDS incorporation, stability, oily nanodroplet formation, increased protection from proteases, and related data charts.

Mixed dry reverse micelles: potential carriers for oral protein delivery via SEDDS

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Flowchart of a chemical reaction, HPLC analysis graph, and stability graphs for HIP under various conditions. Labels include "tuftsin" and "perfluorooctanoic acid."

Evaluation of the dissociation behavior of hydrophobic ion pairs via HPLC analysis

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Flowchart comparing dry addition and organic solvent-aided methods for creating micelles, with Solutol HS15, sorbitan monooleate, and sodium docusate.

Optimizing hydrophilic drug incorporation into SEDDS using dry reverse micelles: a comparative study of preparation methods

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2024

Diagram illustrating HIP formation. Left: chemical structures; Center: HIP formation process; Right: bar charts of payload levels.

Hydrophobic ion pairing: lipophilicity improvement of anionic macromolecules by divalent cation mediated complex formation

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Diagram showing research on semaglutide in drug delivery, including molecular structures, bar graphs on solubility and permeation, and micelle visuals.

Design of self-emulsifying oral delivery systems for semaglutide: reverse micelles versus hydrophobic ion pairs

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Diagram showing a pie chart of F1, F2, F3 SEDDS formulations, a graph of surface hydrophobicity, and a graph of enhanced cellular uptake.

Oral formulations for highly lipophilic drugs: Impact of surface decoration on the efficacy of self-emulsifying drug delivery systems

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Diagram of co-precipitation method: Ethacridine binds with Ca²⁺, Zn²⁺, Fe³⁺, releasing drugs via alkaline phosphatase.

Phosphatase-degradable nanoparticles providing sustained drug release

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Illustration of tissue engineering: components like scaffolds and cells, and applications for organs like heart, liver, and trachea.

Unveiling the potential of biomaterials and their synergistic fusion in tissue engineering

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Diagram showing nanoparticle formation for intracellular delivery, with detailed structure on the left and microscopy images on the right.

The power of sulfhydryl groups: Thiolated lipid-based nanoparticles enhance cellular uptake of nucleic acids

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2023

Diagram illustrating the interaction between nanoemulsions and the intestinal epithelium, highlighting surfactants and the mucus layer.

Power-Up for Mucoadhesiveness: Two Generations of Thiolated Surfactants for Enhanced Sticky Nanoemulsions

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Illustration of drug delivery process: drug solution to polypeptide nanoparticles, encapsulation, administration, and release with graphs for analysis.

Design of biodegradable nanoparticles for enzyme-controlled long-acting drug release

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Diagram illustrating the formulation and analysis of SEDDS for peptide delivery, featuring chemical structures, emulsion process, and stability graphs.

Counterion optimization for hydrophobic ion pairing (HIP): Unraveling the key factors

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Diagram illustrating drug delivery mechanisms with graphs, chemical structures, labeled nanoparticles, and a mouse silhouette.

Development and in vivo evaluation of nanoemulsions for oral delivery of low molecular weight heparin

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Diagram of a drug delivery system showing hydrophobic ion pairing, SEDDS incorporation, and oral administration with a graph and mouse illustration.

Self-emulsifying drug delivery systems (SEDDS): In vivo-proof of concept for oral delivery of insulin glargine

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Diagram showing a drug delivery experiment with ethacridine and HIP. Includes chemical structure, release methods, and graphs of released drug over time.

Hydrophobic Ion Pairing of Small Molecules: How to Minimize Premature Drug Release from SEDDS and Reach the Absorption Membrane in Intact Form

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Diagram of a nanoparticle, showing interactions like targeted drug release, cell penetration, bonds, endocytosis, and charge conversion.

Surface design of nanocarriers: Key to more efficient oral drug delivery systems

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Diagram of drug delivery: salmon calcitonin with hydrophobic ion pair forms nanoemulsion for oral administration, tested on a rat model.

Oral delivery of calcitonin-ion pairs: In vivo proof of concept for a highly lipophilic counterion

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List of publications

Published research

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