Formulation Development

Our advanced drug delivery systems are designed to help you:

• Enhance the bioavailability of your drug

• Improve therapeutic efficacy

• Minimize side effects

• Increase formulation stability

• Achieve tailored delivery profiles to meet specific therapeutic goals, such as: Zero-order release kinetics, Sustained drug release, Targeted drug delivery

• Boost patient compliance

• Create new intellectual property through innovative formulation approaches

Partner with ThioMatrix to transform your formulation challenges into market-ready solutions.

Nasal delivery offers rapid onset of action—ideal for indications such as pain relief and nausea. Peptide drugs, in particular, benefit from enhanced bioavailability via this route when combined with thiomer technology. ThioMatrix provides expertise in the development of nasal delivery systems in liquid, semisolid, or solid forms. Our development process includes:

• Permeation studies on nasal membranes

• Enzymatic stability evaluations

• Cytotoxicity and ciliary beat frequency studies

• System optimization and storage stability testing

• In vivo pharmacokinetic studies in various species

The intraoral mucosa offers sustained drug delivery, avoiding gastrointestinal degradation and first-pass metabolism. With its rich vascularization and lymphatic drainage, it’s a promising route—especially when paired with the mucoadhesive properties of thiomers to ensure prolonged residence. Our services include:

• Buccal permeation studies

• Evaluation of the impact of permeation enhancers

• Mucoadhesion testing

• Formulation design and optimization

The vaginal route offers unique advantages: easy accessibility, large permeation area, high vascularization, low enzymatic activity, and avoidance of first-pass metabolism. It’s especially suited for conditions such as steoporosis, hormone replacement therapy, contraception, infections, and infertility. We specialize in:

• Vaginal permeation studies

• Evaluation of the impact of permeation enhancers

• Mucoadhesion studies

• Enzymatic degradation analysis

• Formulation design and optimization